Following the spirit of the previous meetings we envision a stimulating scientific event where scientists meet in one plenum to present & discuss all aspects of medicinal chemistry. There will be 5 plenary lectures, 20 key lecturers (3-4 of each of the partner countries), a limited number of oral short communications and two poster sessions.
The Abstracts will be published in Scencia Pharmaceutica.
Plenary Lectures
PL-1 Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany
Protein Structure Similarity Clustering (PSSC) and Natural Product Structure as Guiding Principle for Chemical Genomics
PL-2 Sanofi Aventis, Frankfurt am Main, Germany
Strategies for Lead Finding and Lead Optimization utilizing experimental and computational approaches.
PL-3 University of New Mexico, Albuquerque New Mexico, U.S.A.
Pursuing leadlikeness in pharmaceutical research.
PL-4 University of Heidelberg, Germany
From Leads to Drugs
PL-5 University of Bari, Italy
In silico design and focused solid phase synthesis of new, selective enzyme inhibitors with potential in cancer and neurological therapies.
Computer Aided Molecular Design & Virtual Screening
KL-6 ComGenex, Budapest, Hungary
In silico approaches generating novel compound series in lead optimization
KL-7 Institute of Chemistry, University of Silesia, Katowice, Poland
Modeling robust QSAR
KL-8 International Institute of Molecular and Cell Biology, Warsaw, Poland
Functional Oligomers of Rhodopsin - a G Protein-Coupled Receptor Template
KL-9 UniVersidad de Alcala´, Alcala´ de Henares, Madrid, Spain
In silico medicinal chemistry and pharmacology of natural products: understanding biological effects through molecular modelling and molecular dynamics simulations
Alzheimer and Central Nervous System Disorders
KL-10 University of Bologna, Bologna, Italy
Discovery of multipotent drugs for the treatment of Alzheimer's disease
KL-11 EGIS Pharmaceuticals Ltd, Budapest, Hungary
2,3-Benzodiazepines: Multiple Pharmacological Actions and Structure-Activity Relationship
KL-12 Polish Academy of Sciences, Lodz, Poland
Use of short inhibitory nucleic acids for down-regulationof genes of Alzheimer's Disease
KL-13 Universidad Computense, Madrid, Spain
The endogenous cannabinoid system: from the molecules to the therapeutic applications
Medicinal Chemistry Case Studies & Natural Product Synthesis
KL-17
Progress in the Total Synthesis of Polycyclic Natural Products Universität Wien, Vienna, Austria
KL-18 Novartis Institutes for BioMedical Research, Vienna, Austria
Inhibition of Steroid Sulfatase: a New Approach to Treat Estrogen- and Androgen-Dependent Diseases
KL-19 Medical College of Jagiellonian University Krakow, Poland
New development in alfa-1 adrenergic receptors antagonists
KL-20 Boehringer Ingelheim (Canada) Ltd. Laval, Quebec, Canada
The identification of HCV Polymerase inhibitors: A showcase of modern drug discovery
Chemogenomics, Combinchem & other Developing Fields in Medicinal Chemistry
KL-1 IMIM, Barcelona, Spain
Computational chemogenomics: Extracting knowledge from biochemical data
KL-3 NiKem Research s.r.l., Milano, Italy
Microwave-Assisted Highthroughput Chemistry in Lead Generation and Optimization
KL-4 Vienna University of Technology, Vienna, Austria
Lipid rafts and their biological significance
KL-2
Finding Protein Targets for Drugs - The Chemogenetic Approach NIBRI, Cambridge, USA
Oncology
KL-5 Eötvös L. University, Budapest, Hungary
Drug targeting by peptide conjugates
KL-14 Boehringer Ingelheim, Vienna, Austria
Inhibition of the Cell Cycle Kinase CDK1 by 2,4-Diamino-Pyrimidines
KL-15 University of Pécs, Hungary
New PARP inhibitors
KL-16 Nerviano Medical Science s.r.l., Milano, Italy
3-amino-1H-pyrazole derivatives as useful scaffolds for the generation of new kinase inhibitors
Oral Presentations
OP-1 Germany
CHEMICAL MICROARRAYS,- TOOLS FOR HIGH THROUGHPUT FRAGMENT-BASED DRUG DISCOVERY
OP-2 Austria
MICROWAVE ASSISTED AND CONVENTIONAL MONO ARYL SUBSTITUTION OF DIAZABICYCLOALKANES BY ENCAPSULATED PALLADIUM COUPLING
OP-3 Poland
APPLICATION OF SIMULTANEOUS PH AND ORGANIC SOLVENT GRADIENT RP HPLC IN DETERMINATION OF PHARMACOKINETICS-AFFECTING PARAMETERS OF DRUGS
OP-4 Poland
MULTIDISCIPLINARY CHARACTERIZATION OF MOLECULAR INTERACTIONS BETWEEN NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS LIGANDS
OP-5 Austria
3D-QSAR AND VIRTUAL SCREENING OF PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITORS
OP-6 Spain
ADRENOMEDULLIN: A NEW TARGET FOR THE DESIGN AND SYNTHESIS OF DRUGS
OP-7 Italy
NOVEL HIGHLY POTENT ADENOSINE DEAMINASE INHIBITORS CONTAINING THE PYRAZOLO[3,4-D]PYRIMIDINE RING SYSTEM. SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MODELING STUDIES
OP-8 Hungary
SYNTHESIS OF PENTACYCLIC ALKALOID HYBRIDES
OP-9 Italy
NOVEL QINOLIZIDINYL DERIVATIVES AS ANTIARRHYTHMIC AGENTS
OP-10 Italy
N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)-4-ARYL-1-PIPERAZINEALKYLAMIDES AS 5-HT7 RECEPTOR AGENTS
OP-11 United States
STRUCTURE BASED DESIGN OF CATHEPSIN S INHIBITORS
PO-1
Poland
8-Alkoxy-7-phenylpiperazinylalkyl-purine-2,6-diones as 5-HT1A/5-HT2A receptor ligands
PO-2
Poland
NEW ARYLPIPERAZINYLALKYL DERIVATIVES OF 5,5-DISUBSTITUTED HYDANTOINS AS CNS RECEPTOR LIGANDS
PO-3
Poland
Molecular modelling of serotonin 5-HT1A receptor using automated docking of bioactive compounds with defined geometry. Novel approach to GPCR modelling
PO-4
Poland
ARYLPIPERAZINYLALKYL DERIVATIVES OF IMIDAZO[2,1-F]THEOPHYLLINE AS CNS RECEPTOR LIGANDS
PO-5
Poland
Synthesis, anticonvulsant activity and X-ray analysis of new N-(4-arylpiperazin-1-yl)-alkyl-3-spirosuccinimide derivatives
PO-6
Poland
The packing motifs in the crystals of N-substituted succinimides with confirmed anticonvulsant activity
PO-7
Poland
3D-QSAR CoMFA study on theophylline derivatives - adenosine A2A receptor antagonists
PO-8
Poland
TRICYCLIC CYCLOALKYLPURINEDIONES: POTENCY AS ADENOSINE RECEPTOR LIGANDS AND ANTICONVULSANTS
PO-9
Poland
LISOFYLLINE AS A PRODUCT OF IN VITRO BIOTRANSFORMATION OF PENTOXIFYLLINE
PO-10
Poland
(CYCLO)ALKYL 3-PIPERIDINOPROPYL ETHERS AS
HISTAMINE H3 RECEPTOR ANTAGONISTS
PO-11
Poland
BIOTRANSFORMATION OF PRAZIQUANTEL BY
CYTOCHROME C FROM SACCHAROMYCES CEREVISIAE
PO-12
Poland
SYNTHESIS OF 5-SUBSTITUTED HYDANTOINS IN THE MICROWAVE OVEN AND THEIR BIOTRANSFORMATION TO CORRESPONDING NONNATURAL AMINOACIDS USING HYDANTOINASE METHOD
PO-13
Poland
IN SILICO BIOTRANSFORMATION OF BUPRANOLOL
PO-14
Poland
APPLICATION OF MICELLAR LIQUID CHROMATOGRAPHY (MLC) TO DETERMINE LIPOPHILICITY OF NEW PURINDIONE DERIVATIVES OF POTENTIAL ANTICONVULSANT ACTIVITY
PO-15
Poland
TRICYCLIC TRIAZINO- AND TRIAZEPINO[3,4-f] PURINEDIONES: NEW ADENOSINE A1 AND A2A RECEPTOR LIGANDS
PO-16
Poland
AFFINITIES FOR ALPHA1-AR/5-HT1A RECEPTORS AND WATER SOLUBILITY EVALUATION OF PHENYLPIPERAZINE PHENYTOIN DERIVATIVES
PO-17
Poland
Molecular model of 5-HT7 receptor: interaction with arylpiperazine ligands
PO-18
Poland
SYNTHESIS AND SAR STUDIES OF 1,2,3,4-TETRAHYDRO-β-CARBOLINE DERIVATIVES AS NEW 5-HT7/5-HT1A RECEPTOR LIGANDS
PO-19
Iran (Islamic Republic Of)
Synthesis and Biological Evaluation of 4-[2-alkylthio-4(5)-(4-substitutedphenyl) imidazole-5(4)-yl] benzenesufonamides as selective COX-2 inhibitors
PO-20
Russian Federation
SYNTHESIS OF NOVEL GLYCYRRHIZIC ACID CONJUGATES WITH AMINOACIDS POSSESSING IMMUNOMODULATE AND ANTIVIRAL PROPERTIES
PO-21
Russian Federation
DESIGN AND SYNTHESIS OF NOVEL ANTIVIRAL TRITERPENE DERIVATIVES FOR MEDICINE
PO-22
Austria
VIRTUAL DOCKING EXPERIMENTS ON PLEUROMUTILIN DERIVATIVES FUNCTIONALIZED IN POSITION 13
PO-23
Austria
SELECTIVE C-12 EPIMERIZATION OF THE TRICYCLIC SCAFFOLD OF PLEUROMUTILIN (1)
PO-24
Canada
DEVELOPMENT OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE DISORDERS
PO-25
Czech Republic
SUBSTITUTED DIARYLSULFIDES AND THEIR ANTIPLATELET ACTIVITY
PO-26
Spain
DISCOVERY OF NOVEL TETRACYCLIC TETRAHYDROFURAN DERIVATIVES AS POTENT, ORALLY ACTIVE, BROAD SPECTRUM PSYCHOTROPIC AGENTS
PO-27
United Kingdom
STEROID SULPHATASE INHIBITION: FROM CONCEPT TO CLINICAL TRIAL
PO-28
Portugal
NEW 5β,6β-EPOXYSTEROIDS WITH CYTOTOXIC ACTIVITY
PO-29
Hungary
Homology Modelling and Binding Site Mapping of the Human Histamine H1 Receptor
PO-30
Hungary
CoMSIA Study of Oxamide- and Glycineamide-type NR2B Selective NMDA Receptor Antagonists
PO-31
Hungary
CHARACTERISATION OF Na+ CHANNEL BLOCKERS BY A SIMPLE, SPECTROPHOTOMETRIC ASSAY FOR THE DETERMINATION OF GLUTAMATE RELEASE FROM RAT CORTICAL SYNAPTOSOMES
PO-32
Poland
ACTIVITY IN VITRO AND IN VIVO OF NEW DERIVATIVES OF ANTHRACYCLINE ANTIBIOTICS
PO-33
Poland
In vitro cytotoxicity of dextran-methotrexate conjugates is dependent on the molecular weight of the carrier used
PO-34
Hungary
ANTIMICROBIAL ACTIVITY OF CHELIDONIUM ALKALOIDS INVESTIGATED BY BIOARENA SYSTEM
PO-35
United Kingdom
Hit optimisation and SAR of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists
PO-36
Hungary
Synthesis of New Amiodarone Derivatives
PO-37
Poland
THE EFFECT OF RADIATION STERILISATION ON DISULFIRAM IN SOLID STATE
PO-38
Hungary
Preparation of isoindole-condensed heterocycles via retro Diels-Alder reactions
PO-39
Hungary
THE MOST LIKELY BINDING CONFORMATION AND 3D STRUCTURE OF THE BINDING POCKET FOR BENZOXAZINE OXYTOCIN ANTAGONISTS
PO-40
Hungary
INVESTIGATION OF CYTOTOXIC ACTIVITY OF NATURALLY OCCURING ACRIDONE ALKALOIDS
PO-41
Hungary
PHARMACOLOGICAL EVALUATION OF ORIGINALLY SYNTHESIZED ESTRONE AND ESTRADIOL STEREOISOMERS
PO-42
Hungary
SYNTHESIS OF STEROIDAL HETEROCYCLES BY 1,3-DIPOLAR CYCLOADDITION
PO-43
Hungary
SYNTHESIS OF 13ALPHA-DEHIDRO-EPIANDROSTERONE DERIVATIVES BY DOMINO KNOEVENAGEL HETERO DIELS-ALDER REACTION
PO-44
Hungary
STEREOSELECTIVE APPROACH TO SOME NOVEL D-DIHOMO-ESTRONE DERIVATIVES IN THE NORMAL SERIES
PO-45
Poland
NEW DERIVATIVES OF ARYLSULFONYLIMIDAZOLIDINE WITH POTENTIAL PHARMACOLOGICAL ACTIVITY
PO-46
Poland
Opioid activity of new carbonyl derivatives of 1-aryl-2-aminoimidazoline-2
PO-47
Poland
COMPARISON OF E099-25011 AND ITS RIGID OR STERICLY CROWDED ANALOGUES STRUCTURES IN VIEW OF THEIR PHARMACOLOGICAL ACTIVITY
PO-48
Italy
THE ANTITUMOR EFFECTS OF 3’-C-METHYLADENOSINE MEDIATED BY INHIBITION OF RIBONUCLEOTIDE REDUCTASE
PO-49
Italy
STRUCTURE-AFFINITY RELATIONSHIPS OF 5’-CARBAMOYL- AND 5’-THIOCARBAMOYL DERIVATIVES OF THE A1 SELECTIVE ADENOSINE RECEPTOR AGONIST 2’-Me-CCPA AS PARTIAL A1 AGONISTS
PO-50
Italy
2-PHENYL[1,2,3]TRIAZOLO[1,2-a][1,2,4]BENZOTRIAZIN-1-ONE DERIVATIVES AS A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
PO-51
Italy
F2-DABOs ANTAGONIZE CELL PROLIFERATION AND INDUCE CELL DIFFERENTIATION BY INHIBITING A NON-TELOMERIC ENDOGENOUS REVERSE TRANSCRIPTASE
PO-52
Italy
URACIL-BASED HYDROXY-AMIDES (UBHAs) AS A NEW CLASS OF PICOMOLAR HDAC INHIBITORS
PO-53
Italy
(ARYLOXOPROPENYL)PYRROLYL HYDROXYAMIDES AS NOVEL HUMAN CLASS II HISTONE DEACETYLASE INHIBITORS
PO-54
Italy
SYNTHESIS AND BIOLOGICAL EVALUATION OF CURCUMINE ANALOGUES AS APOPTOSIS-INDUCING AGENTS
PO-55
Austria
CONFORMATIONALLY CONSTRAINED ANALOGUES OF THE hFcεRIα STALK PEPTIDE KAPREKY
PO-56
Italy
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PYRROLYLETHANONEAMINE DERIVATIVES, A NOVEL CLASS OF MAO INHIBITORS
PO-57
Italy
DOCKING STUDIES ON BIFUNCTIONAL QUINOLINYL DIKETO ACIDS AS HIV-1 INTEGRASE IHNHIBITORS
PO-58
Italy
SAR STUDIES ON QUINOLINYL-2,4-DIOXOBUTANOIC ACIDS, HIV-1 INTEGRASE INHIBITORS THAT BLOCK HIV-1 REPLICATION IN INFECTED CELLS
PO-59
Italy
DISCOVERY OF NOVEL ANTI-MALARIAL AGENTS:
1-[(ARYL)(4-ARYL-1H-PYRROL-3-YL)METHYL]-1H-IMIDAZOLES TARGETED TO FARNESYL TRANSFERASE
PO-60
Italy
2,4-DIOXO-5-HEXENOIC ACID DERIVATIVES ARE NOVEL SELECTIVE NON-NUCLEOSIDE INHIBITORS OF MAMMALIAN TERMINAL DEOXYNUCLEOTIDYL TRANSFERASES, WITH POTENT CYTOTOXIC EFFECT AGAINST LEUKEMIC CELLS
PO-61
Italy
SAR STUDIES ON INDOLYL DIKETO ACID DERIVATIVES AS HCV RNA-DEPENDENT RNA POLYMERASE INHIBITORS
PO-62
Italy
3D-QSAR MODELS FOR SELECTIVE CLASS I (HD1-B) AND CLASS II (HD1-A) HDAC INHIBITORS
PO-63
Finland
REVERSED AMIDE DERIVATIVES OF ARACHIDONOYL ETHANOL AMIDE - SYNTHESIS, CB1-RECEPTOR ACTIVITY AND ENZYMATIC STABILITY
PO-64
Spain
NEW CHOLINE KINASE INHIBITORS WITH ANTIPROLIFERATIVE ACTIVITY AGAINST ras-TRANSFORMED CELLS
PO-65
Spain
SYNTHESIS OF N-ALKYL-1-PHENYL-5-METHYLSULFONYLINDOL-2-CARBOXAMIDE AS NEW COX-2 SELECTIVE INHIBITORS
PO-66
Spain
DOCKING STUDIES ON THE INHIBITION OF CHOLINE KINASE.
PO-67
Spain
KINURENAMINES AS A NEW TYPE OF POTENT nNOS INHIBITORS
PO-68
Italy
New oxiconazole analogues as antifungal agents
PO-69
Italy
ASSESSMENT OF THE CONFORMATIONAL DEPENDENCE OF THE \'MIPHAK\' DESCRIPTORS FOR IN-SILICO ADME APPROACHES
PO-70
Spain
UNDERSTANDING PPARalpha RECEPTOR ACTIVATION BY TARGETED MOLECULAR DYNAMICS
PO-71
Hungary
QSPR MODELS FOR CATIONIC NEUROTRANSMITTER RECEPTORS: 5-HT1A RECPETOR LIGANDS
PO-72
Hungary
QSPR MODELS FOR CATIONIC NEUROTRANSMITTER RECEPTORS: α1-ADRENOCEPTOR LIGANDS
PO-73
Italy
New anti-viral drugs for the treatment of common cold
PO-74
Portugal
SYNTHESIS AND EVALUATION OF TRIAZENE PRODRUGS AS CANDIDATES FOR MELANOCYTE-DIRECTED ENZYME PRODRUG THERAPY (MDEPT)
PO-75
Portugal
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF DIPEPTIDE ESTERS OF THE ANTI-RETROVIRAL DRUG ACYCLOVIR
PO-76
Portugal
SYNTHESIS OF DIPEPTIDE ESTERS OF AZT AND THEIR INTERACTION WITH THE hPEPT1 PEPTIDE TRANSPORTER
PO-77
Spain
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW TERPENYLFURANES
PO-78
Spain
SYNTHESIS AND CYTOTOXICITY OF NEW 1,4-ANTHRAQUINONES
PO-79
Spain
New Cytotoxic Terpenylnaphthohydroquinones from Myrceocommunic Acid
PO-80
Spain
VASORELAXANT ACTIVITY OF A NEW PHTHALAZINONE. SYNTHESIS AND STUDIES ON THE MECHANISM OF ACTION
PO-81
Spain
ANXIOLYTIC EFFECTS OF PHTHALAZINONES AND HETEROCYCLIC RELATED COMPOUNDS
PO-82
Switzerland
CALPAIN INHIBITORS AS POTENTIAL DRUG CANDIDATES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
PO-83
Austria
New Building Blocks for Drug Synthesis: 4-Acyl-5-hydroxy-1-phenyl-3-trifluoromethylpyrazoles
PO-84
Australia
INHIBITION OF PANTOTHENATE SYNTHETASE, AN ENZYME ON THE PANTOTHENATE PATHWAY
PO-85
Germany
The basal activity of constitutive androstane receptor (CAR) - homology modelling versus X-ray crystallography
PO-86
Austria
SYNTHESIS AND SAR (STRUCTURE ACTIVITY RELATIONSHIP) OF NOVEL BROAD SPECTRUM CEPHALOSPORINS INCLUDING MRSA-ACTIVITY
PO-87
Austria
PREPARATION OF NEW AMINOGUANIDINES AS BUILDING BLOCKS FOR THE SYNTHESIS OF NOVEL HIGHLY ACTIVE CEPHALOSPORINS
PO-88
Germany
NOVEL LEAD STRUCTURES FOR ANTIMALARIAL FARNESYLTRANSFERASE INHIBITORS
PO-89
Germany
Structure-Based Drug Design of New DXR-Inhibitors as Anti-Infective Agents
PO-90
Germany
BENZOPHENONE-BASED FARNESYLTRANSFERASE INHIBITORS AS NOVEL ANTI-MALARIALS
PO-91
Germany
BENZOPHENONE-BASED FARNESYLTRANSFERASE INHIBITORS DISPLAY HIGH ACTIVITY AGAINST TRYPANOSOMATID PARASITES
PO-92
Germany
FARNESYLTRANSFERASE INHIBITORS AS NOVEL AGENTS AGAINST LEISHMANIASIS
PO-93
Germany
Design of new aldose reductase inhibitors - a structure based approach
PO-94
Poland
Preparation and pre-clinical investigation of L-α-methyltyrosine labeled with iodine -131 or iodine-123 (IMT-131I, IMT-123I).
PO-95
Poland
[99m-Tc] TRODAT-1 SYNTHESIS FOR DOPAMINE TRANSPORTER IMAGING.
PO-96
Spain
RESTRICTED Arg-Trp(NPS) AND Trp(NPS)-Arg DERIVATIVES AS TRPV1 RECEPTOR CHANNEL BLOCKERS
PO-97
Italy
1-Substituted 3-(w-aminoalkyl)-1H-indole derivatives as possible s ligands.
PO-98
Italy
Synthesis and antimycobacterial activity of 1,3,4-oxadiazol-2-one derivatives
PO-99
Italy
SAR EVALUATION OF CHIRAL NAPHTYLORFINES WITH ANTINOCICEPTIVE ACTIVITY
PO-100
Italy
RATIONAL APPROACHES TO THE DESIGN OF SELECTIVE SIGMA 1 LIGANDS
PO-101
Italy
SYNTHESIS AND SAR OF NOVEL SIGMA1 SELECTIVE LIGANDS
PO-102
Italy
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES AS NEW POTENTIAL SELECTIVE NOP LIGANDS
PO-103
Italy
COMPUTATIONAL STUDY OF PYRAZOLINE DERIVATIVES PROVIDED WITH POTENT AND SELECTIVE MONOAMINOXIDASE ACTIVITIES
PO-104
Austria
STRUCTURE-BASED PHARMACOPHORE MODELLING WITH LIGANDSCOUT
PO-105
Spain
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF
N-SUBSTITUTED INDOLES AND BENZIMIDAZOLES
AS POTENTIAL HYPNOTIC DRUGS
PO-106
Italy
Exploratory chemistry toward the identification of new classes of MDR reverters
PO-107
Germany
SIDE CHAIN AZASTEROLS AS ERGOSTEROL BIOSYNTHESIS INHIBITORS
PO-108
Italy
NOVEL 5-VINYL-3(2H)-PYRIDAZINONES AS ORALLY ACTIVE ANTINOCICEPTIVE AGENTS
PO-109
Hungary
Synthesis and biological activity of novel pyrimidine derivatives
PO-110
Poland
Reduction reactions of dinitroimidazole derivatives
PO-111
Poland
Microwave assisted synthesis and fragrance properties of heterocyclic analogues of jasmone
PO-112
Poland
NEW METHOD OF SIMULTANEUOS DATERMINATION OF pKa AND log kw EMPLOYING pH-GRADIENT HPLC
PO-113
Spain
NEW CYTOTOXIC TRITERPENEQUINONE DERIVATIVES
PO-114
Spain
3D-QSAR AND PHARMACOPHORE MODELING OF NAPHTHOQUINONE DERIVATIVES WITH CYTOTOXIC ACTIVITY IN HL60 CELL LINES
PO-115
Spain
Synthesis and cytotoxic activity of bis-pyrano-1,4-benzoquinones
PO-116
United Kingdom
Optimisation and pharmacological evaluations of 4-heteroaryl-2-phenylamino-pyrimidine CDK inhibitors
PO-117
Spain
ciclopentadiene as saffold for the synthesys of new active compounds
PO-118
Austria
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL ANTICANCER OXALIPLATIN ANALOGUES
PO-119
Austria
LOW PH IN SOLID TUMORS - SELECTIVE ACTIVATION OF ANTICANCER PLATINUM COMPLEXES
PO-120
Italy
BINDING SELECTIVITY FOR SIGMA RECEPTOR SUBTYPES TRIED
BY NOVEL DIMETHYLPIPERIDINE LIGANDS
PO-121
Hong Kong
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multi-drug resistance phenotype and exhibits antitumor activity in vivo.
PO-122
Belgium
First Dual M3 Antagonists / PDE4 Inhibitors for the Treatment of COPD.
PO-123
Hong Kong
RUTHENIUM PYRAZOLE COMPLEX: POTENT ANTI-CANCER AGENT WITH ANTIANGIOGENIC PROPERTIES
PO-124
Hong Kong
A New Class of Potent Anti-HIV Agents: Oxovanadium(IV) Porphyrin Complexes
PO-125
Italy
STRUCTURE-ACTIVITY HYPOTHESIS IN THE DESIGN OF NEW AMPA RECEPTOR ANTAGONISTS
PO-126
Italy
HIV-1 INTEGRASE INHIBITORS: PHARMACOPHORE MODELING AND RATIONAL DRUG DESIGN
PO-127
Italy
NEW 2,3-BENZODIAZEPINES AS NONCOMPETITIVE AMPA RECEPTOR ANTAGONISTS
PO-128
Austria
SYNTHESIS AND ANTITUMOR STUDIES OF HYDRAZONES DERIVED FROM MONOSUBSTITUED 2-ACETYLPYRIDINES AND 2-HYDRAZINO-1-METHYLBENZIMIDAZOLE
PO-129
Germany
New Inhibitors of Cancer Relevant Protein Kinases
PO-130
Austria
Microwave-Assisted Synthesis of Substituted 2(1H)-Quinolones as Maxi-K+ Channel Openers
PO-131
Austria
Synthesis of 2,4-Dimethyl-8-[2\'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan) and application of microwave assisted organic synthesis
PO-132
Austria WITHDRAWN
SOLID PHASE SUPPORTED SYNTHESIS OF ALKYL DITHIOCARBAMATES
PO-133
Austria
Synthesis of Deuterated Analogs of Pharmaceuticals
PO-134
Poland
STRUCTURE – ACTIVITY STUDIES OF NOVEL AMIDINE ANALOGUES OF MELPHALAN
PO-135
Poland
SYNTHESIS AND CYTOTOXIC PROPERTIES OF NOVEL ALKYLATING DERIVATIVES OF L-PROLINE
PO-136
Poland
POTENTIAL HIV-1 INTEGRASE INHIBITORS: MOLECULAR STRUCTURES OF SELECTED QUINOLINE DERIVATIVES
PO-137
Germany
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF A SMALL-MOLECULE INHIBITOR OF THE HISTONE ACETYLTRANSFERASE GCN5
PO-138
Austria
A NEW GENERATION OF PROGESTERONE RECEPTOR POSITIVE BREAST CANCER THERAPEUTICS: SYNTHESIS AND BIOACTIVITIES
PO-139
Austria
SYNTHESIS AND BIOLOGICAL STUDIES OF A NEW CHROMOPHORE - STEROID CONJUGATE FOR THE PROGESTERONE RECEPTOR
PO-140
Switzerland
Hit&Lead Generation beyond HTS
PO-141
Italy
Extraction and synthesis of monogalactosyl ana monoglucosyl diacylglycerols isolated from Euphorbiaceae
PO-142
Hungary
COMPARATIVE CONFORMATIONAL ANALYSIS OF INDOLICIDIN AND ITS ANALOGUES BY SIMULATED ANNEALING
PO-143
Austria
Improvement of the pharmacological profile of COX-II active resveratrol analogues
PO-144
Italy
SYNTHESIS AND BIOLOGICAL EVALUATION AS PDT/BNCT AGENTS OF Zn(II)- AND Si(IV)-PHTHALOCYANINE DERIVATIVES BEARING BORON CLUSTERS
PO-145
Switzerland
Investigation of multipolar interactions in the active site of thrombin
PO-146
Italy
Pyridazine Derivatives As Novel ACAT Inhibitors
PO-147
Italy
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioids receptors.
PO-148
Italy
Synthesis and cytotoxic activities of 3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-1H-benzo[g]indole and related compounds.
PO-149
Poland
DESIGN AND SYNTHESIS OF NEW DERIVATIVES OF
ALFA-SUBSTITUTED AMIDES OF GAMMA-PHTHALIMIDOBUTYRIC ACID WITH POTENTIAL GABA-ERGIC ACTIVITY
PO-150
Italy
STRUCTURE-ACTIVITY RELATIONSHIPS AND COMPUTATIONAL STUDIES ON PDE4 INHIBITORS
PO-151
Austria
Synthesis and in-vitro Antitumor Activity of 1-[(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds
PO-152
France
MARINE ORGANISMS AS A SOURCE OF THERAPEUTIC AGENTS: NEW BIOACTIVE METABOLITES ISOLATED FROM THE MARINE SPONGE PLAKORTIS ZYGGOMPHA
PO-153
Hungary
NEW ENDOMORPHIN ANALOGUES WITH 2`,6`-DIMETHYL-Tyr AND e-b-MePhe SUBTITUTIONS
PO-154
Hungary
NEW ENDOMORPHIN-2 DERIVATIVES CONTAINING TRITIUM LABELLED 2-AMINOCYCLOPENTANECARBOXYLIC ACID AND 2-AMINOCYCLOHEXANECARBOXILIC ACID
PO-155
Latvia
CYTOTOXICITY OF METALLIC COMPLEXES OF HETARYLTHIOSEMICARBAZONES
PO-156
Italy
2-PHENYL-PYRROLO[2,3-h]QUINOLIN-4-ONES AS NOVEL SELECTIVE ANTIMITOTIC AGENTS
PO-157
Poland
THE PARALLEL SYNTHESIS AND CYTOTOXIC EFFECT
OF CARBOCYCLIC DISTAMYCIN ANALOGUES
PO-158
Germany WITHDRAWN
DISCOVERY OF NOVEL ORALLY ACTIVE, NON-COVALENT DPP-IV INHIBITORS
PO-159
Portugal
XANTHONE DERIVATIVES: NEW INSIGHTS IN ANTITUMOUR ACTIVITY AND RELATED ACTIVITIES
PO-160
Portugal
EFFECTS OF TWO ABIETANES ON MCF-7 BREAST CANCER CELL LINE
PO-161
Portugal
PRENYLATED XANTHONIC DERIVATIVES: SYNTHESIS, STRUCTURE ELUCIDATION AND INHIBITION OF GROWTH OF HUMAN TUMOUR CELL LINES
PO-162
Switzerland
IN SILICO INSIGHTS INTO DNA-BINDING OF
RUTHENIUM(II)-ARENE ANTICANCER COMPOUNDS
PO-163
France
Development of a QSAR model and synthesis of a CNS-focused library
PO-164
Spain
Syntheses and Binding Studies of New 4-(N-Benzylamino)piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with Dual Affinity for Serotonin and Norepinephrine Transporters
PO-165
Spain
Novel 4-Aminopyrimidine Derivatives as Selective COX-2 Inhibitors
PO-166
Italy
SEARCH FOR SELECTIVE ANTAGONISTS AT α1-ADRENORECEPTOR SUBTYPES: WB-4101 RELATED COMPOUNDS
PO-167
Germany
Development of inhibitors of the molecular chaperone HSP90
PO-168
Spain
A hybrid SOM/Fuzzy ARTMAP methodology for the prediction of ecotoxicity in Phenols using molecular descriptors and Modes of Toxic Action
PO-169
Italy
A CHEMOMETRIC APPROACH TO PREDICT A1 AGONIST EFFECT OF ADENOSINE ANALOGUES
PO-170
Italy
MODELLING THE INTERACTION OF STEROID RECEPTORS WITH ORGANIC POLYCHLORINATED COMPOUNDS
PO-171
Germany
Computer aided Property Based Drug Design
PO-172
Italy
2-AMINOBENZENSULFONAMIDES DERIVATIVES AS ALLOSTERIC MODULATORS OF AMPA/KAINATE RECEPTORS
PO-173
Italy
DETERMINATION OF ENANTIOMERIZATION ENERGY BARRIERS BY ENANTIOSELECTIVE STOPPED-FLOW HPLC
PO-174
Austria
APPLICATION OF ROBUST REGRESSION IN QSAR MODELING
PO-175
Italy
TRIAZENE DERIVATIVES ENDOWED WITH ANTIPROLIFERATIVE AND ANTIVIRAL ACTIVITIES
PO-176
Turkey
CoMFA 3D-QSAR STUDIES ON BENZAZOLE DERIVATIVES AS EUKARYOTIC TOPOISOMERASE II INHIBITORS
PO-177
Turkey
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME NEW 5-ETHYLSULPHONYL-2-SUBSTITUTEDBENZOXAZOLES
PO-178
Turkey
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW THIAZOLYL THIAZOLIDINEDIONE DERIVATIVES
PO-179
Turkey
SYNTHESIS AND ANTIDIABETIC ACTIVITY OF SOME NEW 5-(4-OXO-4H-CHROMEN-3-YL-METHYLENE)-THIAZOLIDINE-2,4-DIONES
PO-180
Germany
IRON SALEN COMPLEXES AS NOVEL TUMOR THERAPEUTICS:
CYTOTOXICITY, DNA CLEAVAGE AND ACCUMULATION STUDIES
PO-181
Italy
MODULATION OF THE CONFORMATIONAL BEHEVIOR OF Abeta(25-35) BY INTERACTION WITH TWO POTENT beta-SHEET BREAKER PEPTIDES
PO-182
Greece
IMMOBILIZED ARTIFICIAL MEMBRANE (IAM) CHROMATOGRAPHIC RETENTION FACTORS OF STRUCTURALLY DIVERSE DRUGS AS A MEASURE OF LIPOPHILICITY
PO-183
Slovenia
SELECTIVE AND POTENT 3-AMINO-2-PYRIDINONE AND PYRAZINONE ACETAMIDE THROMBIN INHIBITORS INCORPORATING HETEROBICYCLIC P1-ARGININE MIMETICS
PO-184
Austria
MOLECULAR DYNAMICS STUDY OF MUTANT AND WILD-TYPE HIV-1 PROTEASE TOWARDS RITONAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
PO-185
Austria
Theoretical investigation on structure and function of odorant receptors
PO-186
Italy
AZAPEPTIDOMIMETICS OF MYD88 CONSENSUS PEPTIDE : SYNTHESIS AND PRELIMINARY STUDY ON THEIR EFFECTS
ON IL-1-INDUCED NF-KB ACTIVATION
PO-187
Spain
NEW CARBOXAMIDE DERIVATIVES OF THE BENZO[b]TIOPHENE 1,1-DIOXIDE AS POTENTIAL ANTINEOPLASTIC AGENTS
PO-188
Poland
Analysis of stability of complexes of isonicotinic acid hydrazid derivatives with beta-cyclodekstrin
PO-189
Italy
DESIGN AND SYNTHESIS OF NOVEL DNA BINDERS
PO-190
Italy
SEARCHING FOR NOVEL HIV-1 INTEGRASE INHIBITORS BY 3D-DATABASE VIRTUAL SCREENING
PO-191
Italy
2-[3-[2-(4-CHOROPHENYL)ETHOXY]-PHENYLTHIO]-2-METHYLPROPANOIC ACID, A NEW FIBRATE-LIKE COMPOUND WITH ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY
PO-192
Italy
Rapid Identification of a 5-HT2c antagonist: a synergic approach based on Medicinal and Computational Chemistry
PO-193
Italy
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW 3(5)-METHYL-5(3)-(2-THIOPHENYL AND -2-FURANYL)-1H-1-R-4-CYANOPYRAZOLES
PO-194
United States
Synthesis and SAR of 2-Carboxylic Acid Indoles as Inhibitors of Plasminogen Activator Inhibitor-1
PO-195
Croatia
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 2-AMINO-SUBSTITUTED BENZOTHIAZOLES
PO-196
Italy
DESIGN AND SYNTHESIS OF NOVEL POTENTIAL LIGANDS FOR ENDOTHELIN RECEPTORS
PO-197
Italy
PLASMEPSIN II INHIBITION AND ANTIPLASMODIAL ACTIVITY OF PRIMAQUINE-STATINE “DOUBLE-DRUGS”
PO-198
Italy
INHIBITION OF BACE-1 BY HYDROXYETHYLAMINE AND HYDROXYETHYLSULFIDE ISOSTERIC REPLACEMENTS
PO-199
Italy
SYNTHESIS OF ANALOGUES OF GALLOCATECHIN-3-GALLATE AS INHIBITORS OF METALLOPROTEINASE-9 ACTIVITY AND GENE EXPRESSION
PO-200
Austria
APPLICATION OF MiPhaK ROUTINE TO GENERATE QSAR MODELS FOR PROPAFENONE TYPE P-GLYCOPROTEIN INHIBITORS
PO-201
Austria
SIMILARITY-BASED DESCRIPTORS (SIBAR): A TOOL FOR SAFE EXCHANGE OF CHEMICAL INFORMATION?
PO-202
Hungary
Investigation of Volatile Compounds in Tagetes Species
PO-203
Hungary
Studies on the Anthraquinone Production by Rubia Tinctorum Hairy Root Cultures
PO-204
India
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL PYRAZOLINES FROM 1-(3-METHYL-4-HYDROXY PHENYL)-2-PROPEN-1-ONE AND 1-(3-METHYL-4-HYDROXY PHENYL-FURFURYL-2-PROPEN-1-ONE
PO-205
Hungary
ANTIPSYCHOTIC EFFECT OF GLYCINE REUPTAKE INHIBITION, INDUCED BY ORG-24461 A GLYCINE TRANSPORTER-1 TYPE BLOCKER