Following the spirit of the previous meetings we envision a stimulating scientific event where scientists meet in one plenum to present & discuss all aspects of medicinal chemistry. There will be 5 plenary lectures, 20 key lecturers (3-4 of each of the partner countries), a limited number of oral short communications and two poster sessions.

The Abstracts will be published in Scencia Pharmaceutica.

Plenary Lectures
PL-1 Herbert Waldmann Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany
Protein Structure Similarity Clustering (PSSC) and Natural Product Structure as Guiding Principle for Chemical Genomics

PL-2 Ulrich Stilz Sanofi Aventis, Frankfurt am Main, Germany
Strategies for Lead Finding and Lead Optimization utilizing experimental and computational approaches.

PL-3 Tudor I. Oprea University of New Mexico, Albuquerque New Mexico, U.S.A.
Pursuing leadlikeness in pharmaceutical research.

PL-4 Hugo Kubinyi University of Heidelberg, Germany
From Leads to Drugs

PL-5 Angelo Carotti University of Bari, Italy
In silico design and focused solid phase synthesis of new, selective enzyme inhibitors with potential in cancer and neurological therapies.

Computer Aided Molecular Design & Virtual Screening
KL-6 György Dormán ComGenex, Budapest, Hungary
In silico approaches generating novel compound series in lead optimization

KL-7 Jaroslaw Polanski Institute of Chemistry, University of Silesia, Katowice, Poland
Modeling robust QSAR

KL-8 Slawomir Filipek International Institute of Molecular and Cell Biology, Warsaw, Poland
Functional Oligomers of Rhodopsin - a G Protein-Coupled Receptor Template

KL-9 Federico Gago UniVersidad de Alcala´, Alcala´ de Henares, Madrid, Spain
In silico medicinal chemistry and pharmacology of natural products: understanding biological effects through molecular modelling and molecular dynamics simulations

Alzheimer and Central Nervous System Disorders
KL-10 Carlo Melchiorre University of Bologna, Bologna, Italy
Discovery of multipotent drugs for the treatment of Alzheimer's disease

KL-11 László Harsing EGIS Pharmaceuticals Ltd, Budapest, Hungary
2,3-Benzodiazepines: Multiple Pharmacological Actions and Structure-Activity Relationship

KL-12 Barbara Nawrot Polish Academy of Sciences, Lodz, Poland
Use of short inhibitory nucleic acids for down-regulationof genes of Alzheimer's Disease

KL-13 María L. López-Rodríguez Universidad Computense, Madrid, Spain
The endogenous cannabinoid system: from the molecules to the therapeutic applications

Medicinal Chemistry Case Studies & Natural Product Synthesis
KL-17Johann Mulzer Universität Wien, Vienna, Austria
Progress in the Total Synthesis of Polycyclic Natural Products

KL-18 Peter Nussbaumer Novartis Institutes for BioMedical Research, Vienna, Austria
Inhibition of Steroid Sulfatase: a New Approach to Treat Estrogen- and Androgen-Dependent Diseases

KL-19 Barbara Malawska Medical College of Jagiellonian University Krakow, Poland
New development in alfa-1 adrenergic receptors antagonists

KL-20 Michael Bös Boehringer Ingelheim (Canada) Ltd. Laval, Quebec, Canada
The identification of HCV Polymerase inhibitors: A showcase of modern drug discovery

Chemogenomics, Combinchem & other Developing Fields in Medicinal Chemistry
KL-1 Jordi Mestres IMIM, Barcelona, Spain
Computational chemogenomics: Extracting knowledge from biochemical data

KL-3 Giuseppe A.M. Giardina NiKem Research s.r.l., Milano, Italy
Microwave-Assisted Highthroughput Chemistry in Lead Generation and Optimization

KL-4 Wolfgang Binder Vienna University of Technology, Vienna, Austria
Lipid rafts and their biological significance

KL-2 John Tallarico NIBRI, Cambridge, USA
Finding Protein Targets for Drugs - The Chemogenetic Approach

Oncology
KL-5 Ferenc Hudecz Eötvös L. University, Budapest, Hungary
Drug targeting by peptide conjugates

KL-14 Andreas Schoop Boehringer Ingelheim, Vienna, Austria
Inhibition of the Cell Cycle Kinase CDK1 by 2,4-Diamino-Pyrimidines

KL-15 Kálmán Hideg University of Pécs, Hungary
New PARP inhibitors

KL-16 Mario Varasi Nerviano Medical Science s.r.l., Milano, Italy
3-amino-1H-pyrazole derivatives as useful scaffolds for the generation of new kinase inhibitors

Oral Presentations
OP-1 Hans-Dieter Junker Germany
CHEMICAL MICROARRAYS,- TOOLS FOR HIGH THROUGHPUT FRAGMENT-BASED DRUG DISCOVERY

OP-2 Jaroslav Skubak Austria
MICROWAVE ASSISTED AND CONVENTIONAL MONO ARYL SUBSTITUTION OF DIAZABICYCLOALKANES BY ENCAPSULATED PALLADIUM COUPLING

OP-3 Paweł Wiczling Poland
APPLICATION OF SIMULTANEOUS PH AND ORGANIC SOLVENT GRADIENT RP HPLC IN DETERMINATION OF PHARMACOKINETICS-AFFECTING PARAMETERS OF DRUGS

OP-4 Krzysztof Jozwiak Poland
MULTIDISCIPLINARY CHARACTERIZATION OF MOLECULAR INTERACTIONS BETWEEN NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS LIGANDS

OP-5 Dirk Classen-Houben Austria
3D-QSAR AND VIRTUAL SCREENING OF PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITORS

OP-6 Sonsoles Martin-Santamaria Spain
ADRENOMEDULLIN: A NEW TARGET FOR THE DESIGN AND SYNTHESIS OF DRUGS

OP-7 Antonio Lavecchia Italy
NOVEL HIGHLY POTENT ADENOSINE DEAMINASE INHIBITORS CONTAINING THE PYRAZOLO[3,4-D]PYRIMIDINE RING SYSTEM. SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MODELING STUDIES

OP-8 Máté Bubenyák Hungary
SYNTHESIS OF PENTACYCLIC ALKALOID HYBRIDES

OP-9 Iana Vazzana Italy
NOVEL QINOLIZIDINYL DERIVATIVES AS ANTIARRHYTHMIC AGENTS

OP-10 Marcello Leopoldo Italy
N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)-4-ARYL-1-PIPERAZINEALKYLAMIDES AS 5-HT₇ RECEPTOR AGENTS

OP-11 Michael Graupe United States
STRUCTURE BASED DESIGN OF CATHEPSIN S INHIBITORS

Poster Presentation

PO-1  Grażyna Chłoń-Rzepa  Poland
8-Alkoxy-7-phenylpiperazinylalkyl-purine-2,6-diones as 5-HT1A/5-HT2A receptor ligands

PO-2  Anna Czopek  Poland
NEW ARYLPIPERAZINYLALKYL DERIVATIVES OF 5,5-DISUBSTITUTED HYDANTOINS AS CNS RECEPTOR LIGANDS

PO-3  Marcin Kołaczkowski  Poland
Molecular modelling of serotonin 5-HT1A receptor using automated docking of bioactive compounds with defined geometry. Novel approach to GPCR modelling

PO-4  Agnieszka Zagórska  Poland
ARYLPIPERAZINYLALKYL DERIVATIVES OF IMIDAZO[2,1-F]THEOPHYLLINE AS CNS RECEPTOR LIGANDS

PO-5  Jolanta Obniska  Poland
Synthesis, anticonvulsant activity and X-ray analysis of new N-(4-arylpiperazin-1-yl)-alkyl-3-spirosuccinimide derivatives

PO-6  Janina Karolak-Wojciechowska  Poland
The packing motifs in the crystals of N-substituted succinimides with confirmed anticonvulsant activity

PO-7  Andrzej Fruziński  Poland
3D-QSAR CoMFA study on theophylline derivatives - adenosine A2A receptor antagonists

PO-8  Anna Drabczyńska  Poland
TRICYCLIC CYCLOALKYLPURINEDIONES: POTENCY AS ADENOSINE RECEPTOR LIGANDS AND ANTICONVULSANTS

PO-9  Elzbieta Pekala  Poland
LISOFYLLINE AS A PRODUCT OF IN VITRO BIOTRANSFORMATION OF PENTOXIFYLLINE

PO-10  Kamil Kuder  Poland
(CYCLO)ALKYL 3-PIPERIDINOPROPYL ETHERS AS HISTAMINE H3 RECEPTOR ANTAGONISTS

PO-11  Anna Godawska-Matysik  Poland
BIOTRANSFORMATION OF PRAZIQUANTEL BY CYTOCHROME C FROM SACCHAROMYCES CEREVISIAE

PO-12  Gniewomir Latacz  Poland
SYNTHESIS OF 5-SUBSTITUTED HYDANTOINS IN THE MICROWAVE OVEN AND THEIR BIOTRANSFORMATION TO CORRESPONDING NONNATURAL AMINOACIDS USING HYDANTOINASE METHOD

PO-13  Dorota Zelaszczyk  Poland
IN SILICO BIOTRANSFORMATION OF BUPRANOLOL

PO-14  Piotr Kawczak  Poland
APPLICATION OF MICELLAR LIQUID CHROMATOGRAPHY (MLC) TO DETERMINE LIPOPHILICITY OF NEW PURINDIONE DERIVATIVES OF POTENTIAL ANTICONVULSANT ACTIVITY

PO-15  Olga Yuzlenko  Poland
TRICYCLIC TRIAZINO- AND TRIAZEPINO[3,4-f] PURINEDIONES: NEW ADENOSINE A1 AND A2A RECEPTOR LIGANDS

PO-16  Jadwiga Handzlik  Poland
AFFINITIES FOR ALPHA1-AR/5-HT1A RECEPTORS AND WATER SOLUBILITY EVALUATION OF PHENYLPIPERAZINE PHENYTOIN DERIVATIVES

PO-17  Mateusz Nowak  Poland
Molecular model of 5-HT7 receptor: interaction with arylpiperazine ligands

PO-18  Andrzej J. Bojarski  Poland
SYNTHESIS AND SAR STUDIES OF 1,2,3,4-TETRAHYDRO-β-CARBOLINE DERIVATIVES AS NEW 5-HT7/5-HT1A RECEPTOR LIGANDS

PO-19  Mona Salimi  Iran (Islamic Republic Of)
Synthesis and Biological Evaluation of 4-[2-alkylthio-4(5)-(4-substitutedphenyl) imidazole-5(4)-yl] benzenesufonamides as selective COX-2 inhibitors

PO-20  Lia A. Baltina  Russian Federation
SYNTHESIS OF NOVEL GLYCYRRHIZIC ACID CONJUGATES WITH AMINOACIDS POSSESSING IMMUNOMODULATE AND ANTIVIRAL PROPERTIES

PO-21  Lidia A. Baltina  Russian Federation
DESIGN AND SYNTHESIS OF NOVEL ANTIVIRAL TRITERPENE DERIVATIVES FOR MEDICINE

PO-22  Rosemarie Mang  Austria
VIRTUAL DOCKING EXPERIMENTS ON PLEUROMUTILIN DERIVATIVES FUNCTIONALIZED IN POSITION 13

PO-23  Heinz Berner  Austria
SELECTIVE C-12 EPIMERIZATION OF THE TRICYCLIC SCAFFOLD OF PLEUROMUTILIN (1)

PO-24  Cheuk K. Lau  Canada
DEVELOPMENT OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE DISORDERS

PO-25  Josef Jampilek  Czech Republic
SUBSTITUTED DIARYLSULFIDES AND THEIR ANTIPLATELET ACTIVITY

PO-26  Andrés A. Trabanco  Spain
DISCOVERY OF NOVEL TETRACYCLIC TETRAHYDROFURAN DERIVATIVES AS POTENT, ORALLY ACTIVE, BROAD SPECTRUM PSYCHOTROPIC AGENTS

PO-27  L W Lawrence Woo  United Kingdom
STEROID SULPHATASE INHIBITION: FROM CONCEPT TO CLINICAL TRIAL

PO-28  Vânia M Moreira  Portugal
NEW 5β,6β-EPOXYSTEROIDS WITH CYTOTOXIC ACTIVITY

PO-29  Róbert Kiss  Hungary
Homology Modelling and Binding Site Mapping of the Human Histamine H1 Receptor

PO-30  Ildikó Magdó  Hungary
CoMSIA Study of Oxamide- and Glycineamide-type NR2B Selective NMDA Receptor Antagonists

PO-31  Anikó Gere  Hungary
CHARACTERISATION OF Na+ CHANNEL BLOCKERS BY A SIMPLE, SPECTROPHOTOMETRIC ASSAY FOR THE DETERMINATION OF GLUTAMATE RELEASE FROM RAT CORTICAL SYNAPTOSOMES

PO-32  Malgorzata Wasowska  Poland
ACTIVITY IN VITRO AND IN VIVO OF NEW DERIVATIVES OF ANTHRACYCLINE ANTIBIOTICS

PO-33  Renata Budzynska   Poland
In vitro cytotoxicity of dextran-methotrexate conjugates is dependent on the molecular weight of the carrier used

PO-34  Ágnes Sárközi  Hungary
ANTIMICROBIAL ACTIVITY OF CHELIDONIUM ALKALOIDS INVESTIGATED BY BIOARENA SYSTEM

PO-35  David R Barn  United Kingdom
Hit optimisation and SAR of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

PO-36  Tamás Kálai  Hungary
Synthesis of New Amiodarone Derivatives

PO-37  Barbara Marciniec  Poland
THE EFFECT OF RADIATION STERILISATION ON DISULFIRAM IN SOLID STATE

PO-38  Iván Kanizsai  Hungary
Preparation of isoindole-condensed heterocycles via retro Diels-Alder reactions

PO-39  Balázs Jójárt  Hungary
THE MOST LIKELY BINDING CONFORMATION AND 3D STRUCTURE OF THE BINDING POCKET FOR BENZOXAZINE OXYTOCIN ANTAGONISTS

PO-40  Borbála Réthy  Hungary
INVESTIGATION OF CYTOTOXIC ACTIVITY OF NATURALLY OCCURING ACRIDONE ALKALOIDS

PO-41  Renáta Minorics  Hungary
PHARMACOLOGICAL EVALUATION OF ORIGINALLY SYNTHESIZED ESTRONE AND ESTRADIOL STEREOISOMERS

PO-42  Erzsébet Mernyak  Hungary
SYNTHESIS OF STEROIDAL HETEROCYCLES BY 1,3-DIPOLAR CYCLOADDITION

PO-43  Ágota Szájli  Hungary
SYNTHESIS OF 13ALPHA-DEHIDRO-EPIANDROSTERONE DERIVATIVES BY DOMINO KNOEVENAGEL HETERO DIELS-ALDER REACTION

PO-44  Éva Frank  Hungary
STEREOSELECTIVE APPROACH TO SOME NOVEL D-DIHOMO-ESTRONE DERIVATIVES IN THE NORMAL SERIES

PO-45  Marzena Rządkowska  Poland
NEW DERIVATIVES OF ARYLSULFONYLIMIDAZOLIDINE WITH POTENTIAL PHARMACOLOGICAL ACTIVITY

PO-46  Dariusz Matosiuk  Poland
Opioid activity of new carbonyl derivatives of 1-aryl-2-aminoimidazoline-2

PO-47  Zbigniew Karczmarzyk  Poland
COMPARISON OF E099-25011 AND ITS RIGID OR STERICLY CROWDED ANALOGUES STRUCTURES IN VIEW OF THEIR PHARMACOLOGICAL ACTIVITY

PO-48  Palmarisa Franchetti  Italy
THE ANTITUMOR EFFECTS OF 3’-C-METHYLADENOSINE MEDIATED BY INHIBITION OF RIBONUCLEOTIDE REDUCTASE

PO-49  Loredana Cappellacci  Italy
STRUCTURE-AFFINITY RELATIONSHIPS OF 5’-CARBAMOYL- AND 5’-THIOCARBAMOYL DERIVATIVES OF THE A1 SELECTIVE ADENOSINE RECEPTOR AGONIST 2’-Me-CCPA AS PARTIAL A1 AGONISTS

PO-50  Sabrina Taliani  Italy
2-PHENYL[1,2,3]TRIAZOLO[1,2-a][1,2,4]BENZOTRIAZIN-1-ONE DERIVATIVES AS A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS

PO-51  Gianluca Sbardella  Italy
F2-DABOs ANTAGONIZE CELL PROLIFERATION AND INDUCE CELL DIFFERENTIATION BY INHIBITING A NON-TELOMERIC ENDOGENOUS REVERSE TRANSCRIPTASE

PO-52  Dante Rotili  Italy
URACIL-BASED HYDROXY-AMIDES (UBHAs) AS A NEW CLASS OF PICOMOLAR HDAC INHIBITORS

PO-53  Sergio Valente  Italy
(ARYLOXOPROPENYL)PYRROLYL HYDROXYAMIDES AS NOVEL HUMAN CLASS II HISTONE DEACETYLASE INHIBITORS

PO-54  Gaetano Miele  Italy
SYNTHESIS AND BIOLOGICAL EVALUATION OF CURCUMINE ANALOGUES AS APOPTOSIS-INDUCING AGENTS

PO-55  Carsten Peters  Austria
CONFORMATIONALLY CONSTRAINED ANALOGUES OF THE hFcεRIα STALK PEPTIDE KAPREKY

PO-56  Alessandra Roux  Italy
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PYRROLYLETHANONEAMINE DERIVATIVES, A NOVEL CLASS OF MAO INHIBITORS

PO-57  Roberta Costi  Italy
DOCKING STUDIES ON BIFUNCTIONAL QUINOLINYL DIKETO ACIDS AS HIV-1 INTEGRASE IHNHIBITORS

PO-58  Michela Forte  Italy
SAR STUDIES ON QUINOLINYL-2,4-DIOXOBUTANOIC ACIDS, HIV-1 INTEGRASE INHIBITORS THAT BLOCK HIV-1 REPLICATION IN INFECTED CELLS

PO-59  Carlo Galeffi  Italy
DISCOVERY OF NOVEL ANTI-MALARIAL AGENTS: 1-[(ARYL)(4-ARYL-1H-PYRROL-3-YL)METHYL]-1H-IMIDAZOLES TARGETED TO FARNESYL TRANSFERASE

PO-60  Roberto Di Santo  Italy
2,4-DIOXO-5-HEXENOIC ACID DERIVATIVES ARE NOVEL SELECTIVE NON-NUCLEOSIDE INHIBITORS OF MAMMALIAN TERMINAL DEOXYNUCLEOTIDYL TRANSFERASES, WITH POTENT CYTOTOXIC EFFECT AGAINST LEUKEMIC CELLS

PO-61  Luigi Maria Longo  Italy
SAR STUDIES ON INDOLYL DIKETO ACID DERIVATIVES AS HCV RNA-DEPENDENT RNA POLYMERASE INHIBITORS

PO-62  Silvia Simeoni  Italy
3D-QSAR MODELS FOR SELECTIVE CLASS I (HD1-B) AND CLASS II (HD1-A) HDAC INHIBITORS

PO-63  Teija Parkkari  Finland
REVERSED AMIDE DERIVATIVES OF ARACHIDONOYL ETHANOL AMIDE - SYNTHESIS, CB1-RECEPTOR ACTIVITY AND ENZYMATIC STABILITY

PO-64  Miguel Á. Gallo  Spain
NEW CHOLINE KINASE INHIBITORS WITH ANTIPROLIFERATIVE ACTIVITY AGAINST ras-TRANSFORMED CELLS

PO-65  Joaquín M. Campos  Spain
SYNTHESIS OF N-ALKYL-1-PHENYL-5-METHYLSULFONYLINDOL-2-CARBOXAMIDE AS NEW COX-2 SELECTIVE INHIBITORS

PO-66  Lara Milanese  Spain
DOCKING STUDIES ON THE INHIBITION OF CHOLINE KINASE.

PO-67  Antonio Espinosa  Spain
KINURENAMINES AS A NEW TYPE OF POTENT nNOS INHIBITORS

PO-68  Renata Fringuelli  Italy
New oxiconazole analogues as antifungal agents

PO-69  Gabriele Costantino  Italy
ASSESSMENT OF THE CONFORMATIONAL DEPENDENCE OF THE \'MIPHAK\' DESCRIPTORS FOR IN-SILICO ADME APPROACHES

PO-70  Antonio Entrena  Spain
UNDERSTANDING PPARalpha RECEPTOR ACTIVATION BY TARGETED MOLECULAR DYNAMICS

PO-71  Péter Kovács  Hungary
QSPR MODELS FOR CATIONIC NEUROTRANSMITTER RECEPTORS: 5-HT1A RECPETOR LIGANDS

PO-72  Balazs Balogh  Hungary
QSPR MODELS FOR CATIONIC NEUROTRANSMITTER RECEPTORS: α1-ADRENOCEPTOR LIGANDS

PO-73  C. Maugeri  Italy
New anti-viral drugs for the treatment of common cold

PO-74  Eduarda Mendes  Portugal
SYNTHESIS AND EVALUATION OF TRIAZENE PRODRUGS AS CANDIDATES FOR MELANOCYTE-DIRECTED ENZYME PRODRUG THERAPY (MDEPT)

PO-75  Cláudia Pereira  Portugal
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF DIPEPTIDE ESTERS OF THE ANTI-RETROVIRAL DRUG ACYCLOVIR

PO-76  Cledir Santos  Portugal
SYNTHESIS OF DIPEPTIDE ESTERS OF AZT AND THEIR INTERACTION WITH THE hPEPT1 PEPTIDE TRANSPORTER

PO-77  Leyla Delgado Gómez  Spain
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW TERPENYLFURANES

PO-78  Ana Mª Gamito  Spain
SYNTHESIS AND CYTOTOXICITY OF NEW 1,4-ANTHRAQUINONES

PO-79  Mª Lucena Rodríguez Alonso  Spain
New Cytotoxic Terpenylnaphthohydroquinones from Myrceocommunic Acid

PO-80  Ana E. García-Cadenas  Spain
VASORELAXANT ACTIVITY OF A NEW PHTHALAZINONE. SYNTHESIS AND STUDIES ON THE MECHANISM OF ACTION

PO-81  Alejandro Zamilpa  Spain
ANXIOLYTIC EFFECTS OF PHTHALAZINONES AND HETEROCYCLIC RELATED COMPOUNDS

PO-82  Cyrille Lescop  Switzerland
CALPAIN INHIBITORS AS POTENTIAL DRUG CANDIDATES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

PO-83  Wolfgang Holzer  Austria
New Building Blocks for Drug Synthesis: 4-Acyl-5-hydroxy-1-phenyl-3-trifluoromethylpyrazoles

PO-84  Kellie L. Tuck  Australia
INHIBITION OF PANTOTHENATE SYNTHETASE, AN ENZYME ON THE PANTOTHENATE PATHWAY

PO-85  Björn Windshügel  Germany
The basal activity of constitutive androstane receptor (CAR) - homology modelling versus X-ray crystallography

PO-86  Werner Heilmayer  Austria
SYNTHESIS AND SAR (STRUCTURE ACTIVITY RELATIONSHIP) OF NOVEL BROAD SPECTRUM CEPHALOSPORINS INCLUDING MRSA-ACTIVITY

PO-87  Klaus Thirring  Austria
PREPARATION OF NEW AMINOGUANIDINES AS BUILDING BLOCKS FOR THE SYNTHESIS OF NOVEL HIGHLY ACTIVE CEPHALOSPORINS

PO-88  Katrin Kloth  Germany
NOVEL LEAD STRUCTURES FOR ANTIMALARIAL FARNESYLTRANSFERASE INHIBITORS

PO-89  Johann Perruchon  Germany
Structure-Based Drug Design of New DXR-Inhibitors as Anti-Infective Agents

PO-90  Martin Schlitzer  Germany
BENZOPHENONE-BASED FARNESYLTRANSFERASE INHIBITORS AS NOVEL ANTI-MALARIALS

PO-91  Mirko Altenkämper  Germany
BENZOPHENONE-BASED FARNESYLTRANSFERASE INHIBITORS DISPLAY HIGH ACTIVITY AGAINST TRYPANOSOMATID PARASITES

PO-92  Regina Ortmann  Germany
FARNESYLTRANSFERASE INHIBITORS AS NOVEL AGENTS AGAINST LEISHMANIASIS

PO-93  Michael Eisenmann  Germany
Design of new aldose reductase inhibitors - a structure based approach

PO-94  E. Zakrzewska  Poland
Preparation and pre-clinical investigation of L-α-methyltyrosine labeled with iodine -131 or iodine-123 (IMT-131I, IMT-123I).

PO-95  J. Michalik  Poland
[99m-Tc] TRODAT-1 SYNTHESIS FOR DOPAMINE TRANSPORTER IMAGING.

PO-96  Rosario González-Muñiz  Spain
RESTRICTED Arg-Trp(NPS) AND Trp(NPS)-Arg DERIVATIVES AS TRPV1 RECEPTOR CHANNEL BLOCKERS

PO-97  Maria Grazia Mamolo  Italy
1-Substituted 3-(w-aminoalkyl)-1H-indole derivatives as possible s ligands.

PO-98  Daniele Zampieri  Italy
Synthesis and antimycobacterial activity of 1,3,4-oxadiazol-2-one derivatives

PO-99  Guya Loddo  Italy
SAR EVALUATION OF CHIRAL NAPHTYLORFINES WITH ANTINOCICEPTIVE ACTIVITY

PO-100  Mariangela Urbano  Italy
RATIONAL APPROACHES TO THE DESIGN OF SELECTIVE SIGMA 1 LIGANDS

PO-101  Simona Collina  Italy
SYNTHESIS AND SAR OF NOVEL SIGMA1 SELECTIVE LIGANDS

PO-102  Agostino Marrazzo  Italy
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES AS NEW POTENTIAL SELECTIVE NOP LIGANDS

PO-103  Stefano Alcaro  Italy
COMPUTATIONAL STUDY OF PYRAZOLINE DERIVATIVES PROVIDED WITH POTENT AND SELECTIVE MONOAMINOXIDASE ACTIVITIES

PO-104  Gerhard Wolber  Austria
STRUCTURE-BASED PHARMACOPHORE MODELLING WITH LIGANDSCOUT

PO-105  José Luis Falcó  Spain
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF N-SUBSTITUTED INDOLES AND BENZIMIDAZOLES AS POTENTIAL HYPNOTIC DRUGS

PO-106  Elisabetta Teodori  Italy
Exploratory chemistry toward the identification of new classes of MDR reverters

PO-107  Delphine Renard  Germany
SIDE CHAIN AZASTEROLS AS ERGOSTEROL BIOSYNTHESIS INHIBITORS

PO-108  Vittorio Dal Piaz  Italy
NOVEL 5-VINYL-3(2H)-PYRIDAZINONES AS ORALLY ACTIVE ANTINOCICEPTIVE AGENTS

PO-109  Györgyi Koványi, Lax  Hungary
Synthesis and biological activity of novel pyrimidine derivatives

PO-110  Dorota Olender  Poland
Reduction reactions of dinitroimidazole derivatives

PO-111  Anna Pawełczyk  Poland
Microwave assisted synthesis and fragrance properties of heterocyclic analogues of jasmone

PO-112  Roman Kaliszan  Poland
NEW METHOD OF SIMULTANEUOS DATERMINATION OF pKa AND log kw EMPLOYING pH-GRADIENT HPLC

PO-113  Dulce Mesa-Siverio  Spain
NEW CYTOTOXIC TRITERPENEQUINONE DERIVATIVES

PO-114  Elisa Pérez-Sacau  Spain
3D-QSAR AND PHARMACOPHORE MODELING OF NAPHTHOQUINONE DERIVATIVES WITH CYTOTOXIC ACTIVITY IN HL60 CELL LINES

PO-115  Sandra Jiménez-Alonso  Spain
Synthesis and cytotoxic activity of bis-pyrano-1,4-benzoquinones

PO-116  Janice McLachlan  United Kingdom
Optimisation and pharmacological evaluations of 4-heteroaryl-2-phenylamino-pyrimidine CDK inhibitors

PO-117  Concepción Álvarez  Spain
ciclopentadiene as saffold for the synthesys of new active compounds

PO-118  Markus Galanski  Austria
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL ANTICANCER OXALIPLATIN ANALOGUES

PO-119  Kristof Meelich  Austria
LOW PH IN SOLID TUMORS - SELECTIVE ACTIVATION OF ANTICANCER PLATINUM COMPLEXES

PO-120  Francesco Berardi  Italy
BINDING SELECTIVITY FOR SIGMA RECEPTOR SUBTYPES TRIED BY NOVEL DIMETHYLPIPERIDINE LIGANDS

PO-121  Vincent K.W. Wong  Hong Kong
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multi-drug resistance phenotype and exhibits antitumor activity in vivo.

PO-122  Laurent Provins  Belgium
First Dual M3 Antagonists / PDE4 Inhibitors for the Treatment of COPD.

PO-123  Ella Lai-Ming Wong  Hong Kong
RUTHENIUM PYRAZOLE COMPLEX: POTENT ANTI-CANCER AGENT WITH ANTIANGIOGENIC PROPERTIES

PO-124  Suk-Yu Wong  Hong Kong
A New Class of Potent Anti-HIV Agents: Oxovanadium(IV) Porphyrin Complexes

PO-125  Laura De Luca  Italy
STRUCTURE-ACTIVITY HYPOTHESIS IN THE DESIGN OF NEW AMPA RECEPTOR ANTAGONISTS

PO-126  Maria L. Barreca  Italy
HIV-1 INTEGRASE INHIBITORS: PHARMACOPHORE MODELING AND RATIONAL DRUG DESIGN

PO-127  Silvana Grasso  Italy
NEW 2,3-BENZODIAZEPINES AS NONCOMPETITIVE AMPA RECEPTOR ANTAGONISTS

PO-128  Johnny Easmon Easmon  Austria
SYNTHESIS AND ANTITUMOR STUDIES OF HYDRAZONES DERIVED FROM MONOSUBSTITUED 2-ACETYLPYRIDINES AND 2-HYDRAZINO-1-METHYLBENZIMIDAZOLE

PO-129  Martin Lang  Germany
New Inhibitors of Cancer Relevant Protein Kinases

PO-130  Toma N. Glasnov  Austria
Microwave-Assisted Synthesis of Substituted 2(1H)-Quinolones as Maxi-K+ Channel Openers

PO-131  Klaus Gerdes  Austria
Synthesis of 2,4-Dimethyl-8-[2\'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan) and application of microwave assisted organic synthesis

PO-132  Udo Marquardt  Austria WITHDRAWN
SOLID PHASE SUPPORTED SYNTHESIS OF ALKYL DITHIOCARBAMATES

PO-133  Petr Knesl  Austria
Synthesis of Deuterated Analogs of Pharmaceuticals

PO-134  Anna Bielawska  Poland
STRUCTURE – ACTIVITY STUDIES OF NOVEL AMIDINE ANALOGUES OF MELPHALAN

PO-135  Krzysztof Bielawski  Poland
SYNTHESIS AND CYTOTOXIC PROPERTIES OF NOVEL ALKYLATING DERIVATIVES OF L-PROLINE

PO-136  Katarzyna Majerz-Maniecka  Poland
POTENTIAL HIV-1 INTEGRASE INHIBITORS: MOLECULAR STRUCTURES OF SELECTED QUINOLINE DERIVATIVES

PO-137  Jana Fischer  Germany
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF A SMALL-MOLECULE INHIBITOR OF THE HISTONE ACETYLTRANSFERASE GCN5

PO-138  Claudia Hödl  Austria
A NEW GENERATION OF PROGESTERONE RECEPTOR POSITIVE BREAST CANCER THERAPEUTICS: SYNTHESIS AND BIOACTIVITIES

PO-139  Katrin Raunegger  Austria
SYNTHESIS AND BIOLOGICAL STUDIES OF A NEW CHROMOPHORE - STEROID CONJUGATE FOR THE PROGESTERONE RECEPTOR

PO-140  Konrad H. Bleicher  Switzerland
Hit&Lead Generation beyond HTS

PO-141  Paolo Bonivento  Italy
Extraction and synthesis of monogalactosyl ana monoglucosyl diacylglycerols isolated from Euphorbiaceae

PO-142  Balázs Leitgeb  Hungary
COMPARATIVE CONFORMATIONAL ANALYSIS OF INDOLICIDIN AND ITS ANALOGUES BY SIMULATED ANNEALING

PO-143  Norbert Handler  Austria
Improvement of the pharmacological profile of COX-II active resveratrol analogues

PO-144  Donata Dei  Italy
SYNTHESIS AND BIOLOGICAL EVALUATION AS PDT/BNCT AGENTS OF Zn(II)- AND Si(IV)-PHTHALOCYANINE DERIVATIVES BEARING BORON CLUSTERS

PO-145  Eliane Schweizer  Switzerland
Investigation of multipolar interactions in the active site of thrombin

PO-146  Arianna Gelain  Italy
Pyridazine Derivatives As Novel ACAT Inhibitors

PO-147  Giovanni Loriga  Italy
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioids receptors.

PO-148  Stefania Villa  Italy
Synthesis and cytotoxic activities of 3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-1H-benzo[g]indole and related compounds.

PO-149  Anna Musial  Poland
DESIGN AND SYNTHESIS OF NEW DERIVATIVES OF ALFA-SUBSTITUTED AMIDES OF GAMMA-PHTHALIMIDOBUTYRIC ACID WITH POTENTIAL GABA-ERGIC ACTIVITY

PO-150  Giovanni De Martino  Italy
STRUCTURE-ACTIVITY RELATIONSHIPS AND COMPUTATIONAL STUDIES ON PDE4 INHIBITORS

PO-151  Norbert Haider  Austria
Synthesis and in-vitro Antitumor Activity of 1-[(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds

PO-152  Fabrice Berrué  France
MARINE ORGANISMS AS A SOURCE OF THERAPEUTIC AGENTS: NEW BIOACTIVE METABOLITES ISOLATED FROM THE MARINE SPONGE PLAKORTIS ZYGGOMPHA

PO-153  Erzsébet Szemenyei  Hungary
NEW ENDOMORPHIN ANALOGUES WITH 2`,6`-DIMETHYL-Tyr AND e-b-MePhe SUBTITUTIONS

PO-154  Attila Keresztes  Hungary
NEW ENDOMORPHIN-2 DERIVATIVES CONTAINING TRITIUM LABELLED 2-AMINOCYCLOPENTANECARBOXYLIC ACID AND 2-AMINOCYCLOHEXANECARBOXILIC ACID

PO-155  Edmunds Lukevics  Latvia
CYTOTOXICITY OF METALLIC COMPLEXES OF HETARYLTHIOSEMICARBAZONES

PO-156  Maria Grazia Ferlin  Italy
2-PHENYL-PYRROLO[2,3-h]QUINOLIN-4-ONES AS NOVEL SELECTIVE ANTIMITOTIC AGENTS

PO-157  Danuta Bartulewicz  Poland
THE PARALLEL SYNTHESIS AND CYTOTOXIC EFFECT OF CARBOCYCLIC DISTAMYCIN ANALOGUES

PO-158  Paul John Edwards  Germany WITHDRAWN
DISCOVERY OF NOVEL ORALLY ACTIVE, NON-COVALENT DPP-IV INHIBITORS

PO-159  Emília P. Sousa  Portugal
XANTHONE DERIVATIVES: NEW INSIGHTS IN ANTITUMOUR ACTIVITY AND RELATED ACTIVITIES

PO-160  Cristina Gaspar-Marques  Portugal
EFFECTS OF TWO ABIETANES ON MCF-7 BREAST CANCER CELL LINE

PO-161  Madalena M. M. Pinto  Portugal
PRENYLATED XANTHONIC DERIVATIVES: SYNTHESIS, STRUCTURE ELUCIDATION AND INHIBITION OF GROWTH OF HUMAN TUMOUR CELL LINES

PO-162  Christian Gossens  Switzerland
IN SILICO INSIGHTS INTO DNA-BINDING OF RUTHENIUM(II)-ARENE ANTICANCER COMPOUNDS

PO-163  Rafael Gozalbes  France
Development of a QSAR model and synthesis of a CNS-focused library

PO-164  Pedro L. López Tudanca  Spain
Syntheses and Binding Studies of New 4-(N-Benzylamino)piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with Dual Affinity for Serotonin and Norepinephrine Transporters

PO-165  Aurelio Orjales  Spain
Novel 4-Aminopyrimidine Derivatives as Selective COX-2 Inhibitors

PO-166  Pierfranco Ioan  Italy
SEARCH FOR SELECTIVE ANTAGONISTS AT α1-ADRENORECEPTOR SUBTYPES: WB-4101 RELATED COMPOUNDS

PO-167  Barbara Gioffreda  Germany
Development of inhibitors of the molecular chaperone HSP90

PO-168  Francesc Giralt  Spain
A hybrid SOM/Fuzzy ARTMAP methodology for the prediction of ecotoxicity in Phenols using molecular descriptors and Modes of Toxic Action

PO-169  Luisa Mosti  Italy
A CHEMOMETRIC APPROACH TO PREDICT A1 AGONIST EFFECT OF ADENOSINE ANALOGUES

PO-170  Paola Fossa  Italy
MODELLING THE INTERACTION OF STEROID RECEPTORS WITH ORGANIC POLYCHLORINATED COMPOUNDS

PO-171  Matthias Schöttner  Germany
Computer aided Property Based Drug Design

PO-172  Daniela Braghiroli  Italy
2-AMINOBENZENSULFONAMIDES DERIVATIVES AS ALLOSTERIC MODULATORS OF AMPA/KAINATE RECEPTORS

PO-173  Giuseppe Cannazza  Italy
DETERMINATION OF ENANTIOMERIZATION ENERGY BARRIERS BY ENANTIOSELECTIVE STOPPED-FLOW HPLC

PO-174  Rainer Grohmann  Austria
APPLICATION OF ROBUST REGRESSION IN QSAR MODELING

PO-175  Vito Boido  Italy
TRIAZENE DERIVATIVES ENDOWED WITH ANTIPROLIFERATIVE AND ANTIVIRAL ACTIVITIES

PO-176  İlkay Yildiz  Turkey
CoMFA 3D-QSAR STUDIES ON BENZAZOLE DERIVATIVES AS EUKARYOTIC TOPOISOMERASE II INHIBITORS

PO-177  Özlem Temiz-Arpaci  Turkey
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME NEW 5-ETHYLSULPHONYL-2-SUBSTITUTEDBENZOXAZOLES

PO-178  Oya Bozdağ-Dündar  Turkey
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW THIAZOLYL THIAZOLIDINEDIONE DERIVATIVES

PO-179  Meltem Ceylan-Ünlüsoy  Turkey
SYNTHESIS AND ANTIDIABETIC ACTIVITY OF SOME NEW 5-(4-OXO-4H-CHROMEN-3-YL-METHYLENE)-THIAZOLIDINE-2,4-DIONES

PO-180  Diana Posselt  Germany
IRON SALEN COMPLEXES AS NOVEL TUMOR THERAPEUTICS: CYTOTOXICITY, DNA CLEAVAGE AND ACCUMULATION STUDIES

PO-181  Anna Maria D’Ursi  Italy
MODULATION OF THE CONFORMATIONAL BEHEVIOR OF Abeta(25-35) BY INTERACTION WITH TWO POTENT beta-SHEET BREAKER PEPTIDES

PO-182  Anna Tsantili-Kakoulidou  Greece
IMMOBILIZED ARTIFICIAL MEMBRANE (IAM) CHROMATOGRAPHIC RETENTION FACTORS OF STRUCTURALLY DIVERSE DRUGS AS A MEASURE OF LIPOPHILICITY

PO-183  Lucija Peterlin Mašič  Slovenia
SELECTIVE AND POTENT 3-AMINO-2-PYRIDINONE AND PYRAZINONE ACETAMIDE THROMBIN INHIBITORS INCORPORATING HETEROBICYCLIC P1-ARGININE MIMETICS

PO-184  Ornjira Aruksakunwong  Austria
MOLECULAR DYNAMICS STUDY OF MUTANT AND WILD-TYPE HIV-1 PROTEASE TOWARDS RITONAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE

PO-185  Anna Stary  Austria
Theoretical investigation on structure and function of odorant receptors

PO-186  Nicola Fantò  Italy
AZAPEPTIDOMIMETICS OF MYD88 CONSENSUS PEPTIDE : SYNTHESIS AND PRELIMINARY STUDY ON THEIR EFFECTS ON IL-1-INDUCED NF-KB ACTIVATION

PO-187  Victor Martinez-Merino  Spain
NEW CARBOXAMIDE DERIVATIVES OF THE BENZO[b]TIOPHENE 1,1-DIOXIDE AS POTENTIAL ANTINEOPLASTIC AGENTS

PO-188  Wiktor Jurkowski  Poland
Analysis of stability of complexes of isonicotinic acid hydrazid derivatives with beta-cyclodekstrin

PO-189  Marco Derudas  Italy
DESIGN AND SYNTHESIS OF NOVEL DNA BINDERS

PO-190  Luciano Sannia  Italy
SEARCHING FOR NOVEL HIV-1 INTEGRASE INHIBITORS BY 3D-DATABASE VIRTUAL SCREENING

PO-191  N. Dell'Uomo  Italy
2-[3-[2-(4-CHOROPHENYL)ETHOXY]-PHENYLTHIO]-2-METHYLPROPANOIC ACID, A NEW FIBRATE-LIKE COMPOUND WITH ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY

PO-192  Luca Tarsi  Italy
Rapid Identification of a 5-HT2c antagonist: a synergic approach based on Medicinal and Computational Chemistry

PO-193  Stefania Aiello  Italy
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW 3(5)-METHYL-5(3)-(2-THIOPHENYL AND -2-FURANYL)-1H-1-R-4-CYANOPYRAZOLES

PO-194  Baihua Hu  United States
Synthesis and SAR of 2-Carboxylic Acid Indoles as Inhibitors of Plasminogen Activator Inhibitor-1

PO-195  Irena Ćaleta  Croatia
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 2-AMINO-SUBSTITUTED BENZOTHIAZOLES

PO-196  Valeria Pittalà  Italy
DESIGN AND SYNTHESIS OF NOVEL POTENTIAL LIGANDS FOR ENDOTHELIN RECEPTORS

PO-197  Sergio Romeo  Italy
PLASMEPSIN II INHIBITION AND ANTIPLASMODIAL ACTIVITY OF PRIMAQUINE-STATINE “DOUBLE-DRUGS”

PO-198  Luca Rizzi  Italy
INHIBITION OF BACE-1 BY HYDROXYETHYLAMINE AND HYDROXYETHYLSULFIDE ISOSTERIC REPLACEMENTS

PO-199  Silvia Stefanini  Italy
SYNTHESIS OF ANALOGUES OF GALLOCATECHIN-3-GALLATE AS INHIBITORS OF METALLOPROTEINASE-9 ACTIVITY AND GENE EXPRESSION

PO-200  Barbara Zdrazil  Austria
APPLICATION OF MiPhaK ROUTINE TO GENERATE QSAR MODELS FOR PROPAFENONE TYPE P-GLYCOPROTEIN INHIBITORS

PO-201  Dominik Kaiser  Austria
SIMILARITY-BASED DESCRIPTORS (SIBAR): A TOOL FOR SAFE EXCHANGE OF CHEMICAL INFORMATION?

PO-202  Szabolcs Szarka  Hungary
Investigation of Volatile Compounds in Tagetes Species

PO-203  Péter Bányai  Hungary
Studies on the Anthraquinone Production by Rubia Tinctorum Hairy Root Cultures

PO-204  M. Shahar yar  India
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL PYRAZOLINES FROM 1-(3-METHYL-4-HYDROXY PHENYL)-2-PROPEN-1-ONE AND 1-(3-METHYL-4-HYDROXY PHENYL-FURFURYL-2-PROPEN-1-ONE

PO-205  Andrea Czompa  Hungary
ANTIPSYCHOTIC EFFECT OF GLYCINE REUPTAKE INHIBITION, INDUCED BY ORG-24461 A GLYCINE TRANSPORTER-1 TYPE BLOCKER